Resistance Mechanisms to Methotrexate in Tumors
نویسندگان
چکیده
منابع مشابه
Resistance Mechanisms to Methotrexate in Tumors.
The mechanisms of intrinsic and acquired resistance to methotrexate (MTX) in human tumors are reviewed herein. In blasts from patients with acute lymphocytic leukemia, resistance mechanisms found are decreased uptake and increased dihydrofolate reductase (DHFR) activity. A major cause of intrinsic resistance to MTX in soft tissue sarcoma cells and in acute myelocytic leukemia appears to be a la...
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High-dose methotrexate is a major component of current protocols for the treatment of osteosarcoma, but some tumors seem to be resistant. Potential mechanisms of resistance include decreased transport through the reduced folate carrier (RFC) and increased expression of dihydrofolate reductase (DHFR). To investigate methotrexate resistance, tumors were obtained from 42 patients with high-grade o...
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The biochemical basis for the resistance of murine leukemia P388 to 5-fluorouracil (FUra) was sytematically investigated by examining the transport and metabolism of FUra, or its anabolites, as well as the inhibition of enzymes and processes known to be affected by the drug. Of these parameters, only three were found to be altered significantly in the resistant line: (a) the enzyme required for...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 1996
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.1-4-223